Jyoti Mishra, Ph.D.

Fellow In Child & Adolescent ADHD

Project Details


Adam Gazzaley, M.D., Ph.D.
Keith McBurnett, Ph.D.


University of California San Francisco


A Novel Cognitive Brain Computer Interface (cBCI) for Attention Deficit Disorder


A Novel Cognitive Brain Computer Interface (cBCI) for Attention Deficit Disorder

Project Summary

The main aim of this project is to test the feasibility of a novel cBCI technology for remediation of attention and related cognitive deficits in adolescents with attention deficit hyperactivity disorder. Brain computer interfaces (BCIs) allow the user to interact with computerized digital environments using their brain signals. Yet, BCIs that can rehabilitate impaired cognition have not been successfully developed. The Neuroscape Lab at UCSF developed a novel “Glass Brain” cBCI neurofeedback technology, which is the most anatomically accurate 3D model of real time human brain activity currently available. When applied to ADHD, the “Glass Brain” cBCI will enable users to improve their attention-related neural processing in a personalized and targeted manner. 

The project hypothesizes that it will be feasible to administer multiple sessions of engaging and immersive novel cBCI training in adolescents with ADHD in a single-arm open label study. The secondary hypothesis is that this training will generate significant improvements in attention and related cognitive abilities as measured by a standard cognitive test battery and that it will improve ADHD symptoms as measured by self & observer ADHD rating scales. The study will be conducted as a single-arm open-label feasibility trial of cBCI in adolescent children with ADHD. Ten sessions of cBCI training distributed over a 5 week period will be flanked by baseline, post-assessment, and 6-month follow-up assessments measuring cognitive function, ADHD symptoms and academic (reading & math) fluency.

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