Yale University Archives - Klingenstein Philanthropies

PROJECT TITLE The use of movies to assay brain network dynamics in ADHD PROJECT SUMMARY For years, scientists, clinicians and parents have been making observations about temporal patterns in attention-deficit/hyperactivity disorder (ADHD). For example, the errors made by children with ADHD during behavioral tasks fluctuate over periods of minutes, suggesting that the brain systems involved…

April 21, 2021

Hanna E. Stevens, M.D., Ph.D.

PROJECT TITLE Gene-environment interaction and ADHD: translation between rodent and human models of prenatal stress, genetic risk, and postnatal environment PROJECT SUMMARY Maternal stress during pregnancy has been associated with ADHD, particularly hyperactive and impulsive symptoms. However, prenatal stress is often correlated with postnatal stress which may influence childhood development. Therefore, it has been difficult…

April 21, 2021

Jessica Kalmar, M.D., Ph.D.

PROJECT title Developing Neurobehavioral Endophenotypes to Dissociate Pediatric Major Depressive and Bipolar Disorders PROJECT SUMMARY Pediatric major depressive disorder (MDD) is difficult to distinguish from bipolar disorder (BD) as depression frequently presents first in children with BD. Methods to dissociate MDD from BD in youth are needed critically in order to prevent the severe consequences…

April 21, 2021

V. Robin Weersing, Ph.D.

April 21, 2021

Anjali Sankar, Ph.D.

PROJECT TITLE An early targeted psychobehavioral intervention for depressed adolescents at risk for bipolar disorder PROJECT SUMMARY Adolescence is a critical period for individuals vulnerable to developing Bipolar Disorder (BD), as this is often when initial symptoms transition to fully syndromal BD. It is also a time when the brain circuitry subserving emotion regulation, central…

April 21, 2021

Jennifer Dwyer, M.D., Ph.D.

PROJECT TITLE Ketamine for severe adolescent depression: intermediate-term safety and efficacy PROJECT SUMMARY Nearly one in four adolescents will experience major depressive disorder, and suicide is the 2nd leading cause of death in this age group. Forty percent of adolescents with depression fail to respond to initial treatment with selective serotonin reuptake inhibitors. Of this…

April 21, 2021

Emily Olfson, M.D., Ph.D.

PROJECT TITLE Whole-Exome Sequencing Study of Parent-Child Trios with ADHD PROJECT SUMMARY Attention-deficit/hyperactivity disorder (ADHD) is among the most heritable of psychiatric disorders, so identifying genes contributing to ADHD risk is a key step towards understanding this disease process and improving treatments. However, decades of candidate gene studies have not identified reproducible findings, and only…

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Hongying Shen, Ph.D.

James Jeanne, Ph.D.

Liang Liang, Ph.D.

Junjie Guo, Ph.D.

Michael J. Higley, Ph.D.

Jessica A. Cardin, Ph.D.

Daniel A. Colon-Ramos, Ph.D.

Susumu Tomita, Ph.D.

Elke Stein, Ph.D.

David A. McCormick, Ph.D.

John F. Tallman, Ph.D.

Susan J. Hockfield, Ph.D.

Leonard K. Kaczmarek, Ph.D.

Tamara Vanderwal, M.D.

Hanna E. Stevens, M.D., Ph.D.

Jessica Kalmar, M.D., Ph.D.

V. Robin Weersing, Ph.D.

Anjali Sankar, Ph.D.

Jennifer Dwyer, M.D., Ph.D.

Emily Olfson, M.D., Ph.D.